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Glucose promotes secretion-dependent renal cyst growth

Kraus, Andre ; Schley, Gunnar ; Kunzelmann, Karl ; Schreiber, Rainer ; Peters, Dorien J. M. ; Stadler, Ruth ; Eckardt, Kai-Uwe ; Buchholz, Bjoern


Polycystic kidney diseases are characterized by the development of numerous bilateral renal cysts that continuously enlarge resulting in a decline of kidney function due to compression of intact nephrons. Cyst growth is driven by transepithelial chloride secretion which depends on both intracellular cAMP and calcium. Mechanisms that are involved in the regulation of the underlying secretory ...


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