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Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells

Clara, Renan Orsati ; Assmann, Nadine ; Ramos Moreno, Ana Carolina ; Coimbra, Janine Baptista ; Nurenberger, Nadine ; Dettmer-Wilde, Katja ; Oefner, Peter Josef ; Campa, Ana



Abstract

A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-gamma (IFN-gamma) and related to poor prognosis in melanomas. Besides its role in cancer, IFN-gamma plays a key role in the control of pigmentation homeostasis. Here we measured KP metabolites in human ...

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