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Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist

Cao, Benjamin ; Zhang, Zhen ; Grassinger, Jochen ; Williams, Brenda ; Heazlewood, Chad K. ; Churches, Quentin I. ; James, Simon A. ; Li, Songhui ; Papayannopoulou, Thalia ; Nilsson, Susan K.



Abstract

The inherent disadvantages of using granulocyte colony-stimulating factor (G-CSF) for hematopoietic stem cell (HSC) mobilization have driven efforts to identify alternate strategies based on single doses of small molecules. Here, we show targeting alpha(9)beta(1)/alpha(4)beta(1) integrins with a single dose of a small molecule antagonist (BOP ...

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