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Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts

Schwantes-An, Tae-Hwi ; Zhang, Juan ; Chen, Li-Shiun ; Hartz, Sarah M. ; Culverhouse, Robert C. ; Chen, Xiangning ; Coon, Hilary ; Frank, Josef ; Kamens, Helen M. ; Konte, Bettina ; Kovanen, Leena ; Latvala, Antti ; Legrand, Lisa N. ; Maher, Brion S. ; Melroy, Whitney E. ; Nelson, Elliot C. ; Reid, Mark W. ; Robinson, Jason D. ; Shen, Pei-Hong ; Yang, Bao-Zhu ; Andrews, Judy A. ; Aveyard, Paul ; Beltcheva, Olga ; Brown, Sandra A. ; Cannon, Dale S. ; Cichon, Sven ; Corley, Robin P. ; Dahmen, Norbert ; Degenhardt, Louisa ; Foroud, Tatiana ; Gaebel, Wolfgang ; Giegling, Ina ; Glatt, Stephen J. ; Grucza, Richard A. ; Hardin, Jill ; Hartmann, Annette M. ; Heath, Andrew C. ; Herms, Stefan ; Hodgkinson, Colin A. ; Hoffmann, Per ; Hops, Hyman ; Huizinga, David ; Ising, Marcus ; Johnson, Eric O. ; Johnstone, Elaine ; Kaneva, Radka P. ; Kendler, Kenneth S. ; Kiefer, Falk ; Kranzler, Henry R. ; Krauter, Ken S. ; Levran, Orna ; Lucae, Susanne ; Lynskey, Michael T. ; Maier, Wolfgang ; Mann, Karl ; Martin, Nicholas G. ; Mattheisen, Manuel ; Montgomery, Grant W. ; Müller-Myhsok, Bertram ; Murphy, Michael F. ; Neale, Michael C. ; Nikolov, Momchil A. ; Nishita, Denise ; Nöthen, Markus M. ; Nurnberger, John ; Partonen, Timo ; Pergadia, Michele L. ; Reynolds, Maureen ; Ridinger, Monika ; Rose, Richard J. ; Rouvinen-Lagerström, Noora ; Scherbaum, Norbert ; Schmäl, Christine ; Soyka, Michael ; Stallings, Michael C. ; Steffens, Michael ; Treutlein, Jens ; Tsuang, Ming ; Wall, Tamara L. ; Wodarz, Norbert ; Yuferov, Vadim ; Zill, Peter ; Bergen, Andrew W. ; Chen, Jingchun ; Cinciripini, Paul M. ; Edenberg, Howard J. ; Ehringer, Marissa A. ; Ferrell, Robert E. ; Gelernter, Joel ; Goldman, David ; Hewitt, John K. ; Hopfer, Christian J. ; Iacono, William G. ; Kaprio, Jaakko ; Kreek, Mary Jeanne ; Kremensky, Ivo M. ; Madden, Pamela A.F. ; McGue, Matt ; Munafò, Marcus R. ; Philibert, Robert A. ; Rietschel, Marcella ; Roy, Alec ; Rujescu, Dan ; Saarikoski, Sirkku T. ; Swan, Gary E. ; Todorov, Alexandre A. ; Vanyukov, Michael M. ; Weiss, Robert B. ; Bierut, Laura J. ; Saccone, Nancy L.



Abstract

The mu1 opioid receptor gene, OPRM1, has long been a high-priority candidate for human genetic studies of addiction. Because of its potential functional significance, the non-synonymous variant rs1799971 (A118G, Asn40Asp) in OPRM1 has been extensively studied, yet its role in addiction has remained unclear, with conflicting association findings. To resolve the question of what effect, if any, ...

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