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Homozygous G/G variant of SNP309 in the human MDM2 gene is associated with earlier tumor onset in Caucasian female renal cell carcinoma patients

Stoehr, C. G. ; Stoehr, R. ; Wenners, A. ; Hartmann, A. ; Bertz, S. ; Spath, V. ; Walter, B. ; Junker, K. ; Moch, H. ; Hinze, R. ; Denzinger, S. ; Bond, E. E. ; Bond, G. L. ; Bluemke, K. ; Weigelt, K. ; Lieb, V. ; Nolte, E. ; Fornara, P. ; Wullich, B. ; Taubert, H. ; Wach, S.


Human mouse double minute 2 (Mdm2) plays an essential role in the regulation of the tumor suppressor p53. The G/G variant of SNP309 was shown to increase Mdm2 mRNA/protein expression and to be associated with an increased risk and earlier onset of different cancers in Asian populations. However, the frequency and impact of these G/G variants have not been studied in Caucasian renal cell carcinoma ...


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