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Recombinant hTRBP and hPACT Modulate hAgo2-Catalyzed siRNA-Mediated Target RNA Cleavage In Vitro

Maga, Giovanni ; Willkomm, Sarah ; Deerberg, Andrea ; Heidemann, Johannes ; Flügge, Friedemann ; Meine, Janica ; Hu, Rui ; Kretschmer-Kazemi Far, Rosel ; Restle, Tobias


The human TAR RNA-binding protein (hTRBP) and protein activator of protein kinase R (hPACT) are important players in RNA interference (RNAi). Together with hArgonaute2 (hAgo2) and hDicer they have been reported to form the RISC-loading complex (RLC). Among other functions, hTRBP was suggested to assist the loading of hAgo2 with small interfering RNAs (siRNAs) within the RLC. Although several ...


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