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Perioperative blood loss and gastrointestinal tolerability of etoricoxib and diclofenac in total hip arthroplasty (ETO-DIC study): a single-center, prospective double-blinded randomized controlled trial

Winkler, Sebastian H. ; Barta, Sabine ; Kehl, Victoria ; Schröter, Christoph ; Wagner, Ferdinand ; Grifka, Joachim ; Springorum, Hans Robert ; Craiovan, Benjamin


Objective: Non-selective NSAIDs can cause serious gastrointestinal side-effects. Selective COX-2 blockers are a reasonable alternative for pain treatment. They do not seem to affect platelet function and consequently cause a lower perioperative blood loss than non-selective NSAIDs. This study compared etoricoxib and diclofenac during a perioperative (9 days) period after THA to investigate total ...


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