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Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells

Seebauer, Caroline Theresa ; Brunner, Stefan ; Glockzin, Gabriel ; Piso, Pompiliu ; Ruemmele, Petra ; Schlitt, Hans-Juergen ; Geissler, Edward Kenneth ; Fichtner-Feigl, Stefan ; Kesselring, Rebecca



Abstract

Background: Peritoneal carcinomatosis (PC) is a terminal evolution from primary colorectal cancer (pCRC) associated with poor patient survival. Impact of the immune cell infiltrate on PC pathogenesis is unknown. Therefore, we characterized the immunological tumor microenvironment regarding proliferation, senescence and neovascularization. Methods: Formalin-fixed and paraffin-embedded (FFPE) ...

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