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TERT Core Promotor Mutations in Early-Onset Bladder Cancer

Giedl, Johannes ; Rogler, Anja ; Wild, Andreas ; Riener, Marc-Oliver ; Filbeck, Thomas ; Burger, Maximilian ; Rümmele, Petra ; Hurst, Carolyn ; Knowles, Margaret ; Hartmann, Arndt ; Zinnall, Ulrike ; Stoehr, Robert



Abstract

Activating mutations in the core promoter of the TERT gene have been described in many different tumor entities. In vitro models showed a two-to fourfold increase in transcriptional activity of the TERT promoter through creation of a consensus binding motif for Ets/TCF transcription factors caused by these mutations. TERT core promoter mutations are the most common mutations in bladder cancer ...

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