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Cre recombinase expression or topical tamoxifen treatment do not affect retinal structure and function, neuronal vulnerability or glial reactivity in the mouse eye

Boneva, S.K. ; Groß, T.R. ; Schlecht, A. ; Schmitt, S.I. ; Sippl, C. ; Jägle, H. ; Volz, C. ; Neueder, A. ; Tamm, E.R. ; Braunger, B.M.



Abstract

Mice with a constitutive or tamoxifen-induced Cre recombinase (Cre) expression are frequently used research tools to allow the conditional deletion of target genes via the Cre-loxP system. Here we analyzed for the first time in a comprehensive and comparative way, whether retinal Cre expression or topical tamoxifen treatment itself would cause structural or functional changes, including changes ...

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