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Upregulation of inflammasome activity and increased gut permeability are associated with obesity in children and adolescents

Rainone, V. ; Schneider, L. ; Saulle, I. ; Ricci, C. ; Biasin, M. ; Al-Daghri, N. M. ; Giani, E. ; Zuccotti, G. V. ; Clerici, M. ; Trabattoni, D.



Abstract

BACKGROUND: Immune activation contributes to the persistent state of inflammation associated with metabolic dysfunction in obesity. The specific immune receptors that sense metabolic stress signals and trigger inflammation are nevertheless largely unknown, and little is known on inflammatory and immune gene regulation in obesity. METHODS: The study includes a cross-sectional and a longitudinal ...

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