




Item type: | Article | ||||
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Journal or Publication Title: | Proceedings of the National Academy of Sciences | ||||
Publisher: | NATL ACAD SCIENCES | ||||
Place of Publication: | WASHINGTON | ||||
Volume: | 113 | ||||
Number of Issue or Book Chapter: | 22 | ||||
Page Range: | E3130-E3139 | ||||
Date: | 2016 | ||||
Institutions: | Medicine > Lehrstuhl für Immunologie | ||||
Identification Number: |
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Keywords: | CHRONIC PSYCHOSOCIAL STRESS; INFLAMMATORY-BOWEL-DISEASE; REGULATORY T-CELLS; MESSENGER-RNA EXPRESSION; DORSAL RAPHE NUCLEUS; EARLY-LIFE STRESS; SEROTONERGIC NEURONS; HELICOBACTER-PYLORI; SOCIAL STRESS; INTESTINAL MICROBIOTA; anxiety; chronic psychosocial stress; fear; microbiota; posttraumatic stress disorder | ||||
Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
Status: | Published | ||||
Refereed: | Yes, this version has been refereed | ||||
Created at the University of Regensburg: | Yes | ||||
Item ID: | 42195 |
Abstract
The prevalence of inflammatory diseases is increasing in modern urban societies. Inflammation increases risk of stress-related pathology; consequently, immunoregulatory or antiinflammatory approaches may protect against negative stress-related outcomes. We show that stress disrupts the homeostatic relationship between the microbiota and the host, resulting in exaggerated inflammation. Repeated ...

Abstract
The prevalence of inflammatory diseases is increasing in modern urban societies. Inflammation increases risk of stress-related pathology; consequently, immunoregulatory or antiinflammatory approaches may protect against negative stress-related outcomes. We show that stress disrupts the homeostatic relationship between the microbiota and the host, resulting in exaggerated inflammation. Repeated immunization with a heat-killed preparation of Mycobacterium vaccae, an immunoregulatory environmental microorganism, reduced subordinate, flight, and avoiding behavioral responses to a dominant aggressor in a murine model of chronic psychosocial stress when tested 1-2wk following the final immunization. Furthermore, immunization with M. vaccae prevented stress-induced spontaneous colitis and, in stressed mice, induced anxiolytic or fear-reducing effects as measured on the elevated plus-maze, despite stress-induced gut microbiota changes characteristic of gut infection and colitis. Immunization with M. vaccae also prevented stress-induced aggravation of colitis in a model of inflammatory bowel disease. Depletion of regulatory T cells negated protective effects of immunization with M. vaccae on stress-induced colitis and anxiety-like or fear behaviors. These data provide a framework for developing microbiome- and immunoregulation-based strategies for prevention of stress-related pathologies.
Metadata last modified: 17 Mar 2020 11:26