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Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice

Reber, Stefan O. ; Siebler, Philip H. ; Donner, Nina C. ; Morton, James T. ; Smith, David G. ; Kopelman, Jared M. ; Lowe, Kenneth R. ; Wheeler, Kristen J. ; Fox, James H. ; Hassell, James E. ; Greenwood, Benjamin N. ; Jansch, Charline ; Lechner, Anja ; Schmidt, Dominic ; Uschold-Schmidt, Nicole ; Füchsl, Andrea M. ; Langgartner, Dominik ; Walker, Frederick R. ; Hale, Matthew W. ; Lopez Perez, Gerardo ; Van Treuren, Will ; González, Antonio ; Halweg-Edwards, Andrea L. ; Fleshner, Monika ; Raison, Charles L. ; Rook, Graham A. ; Peddada, Shyamal D. ; Knight, Rob ; Lowry, Christopher A.


The prevalence of inflammatory diseases is increasing in modern urban societies. Inflammation increases risk of stress-related pathology; consequently, immunoregulatory or antiinflammatory approaches may protect against negative stress-related outcomes. We show that stress disrupts the homeostatic relationship between the microbiota and the host, resulting in exaggerated inflammation. Repeated ...


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