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Cognitive Effects of High-Frequency rTMS in Schizophrenia Patients With Predominant Negative Symptoms: Results From a Multicenter Randomized Sham-Controlled Trial

Hasan, Alkomiet ; Guse, Birgit ; Cordes, Joachim ; Wölwer, Wolfgang ; Winterer, Georg ; Gaebel, Wolfgang ; Langguth, Berthold ; Landgrebe, Michael ; Eichhammer, Peter ; Frank, Elmar ; Hajak, Göran ; Ohmann, Christian ; Verde, Pablo E. ; Rietschel, Marcella ; Ahmed, Raees ; Honer, William G. ; Malchow, Berend ; Karch, Susanne ; Schneider-Axmann, Thomas ; Falkai, Peter ; Wobrock, Thomas



Abstract

Cognitive impairments are one of the main contributors to disability and poor long-term outcome in schizophrenia. Proof-of-concept trials indicate that repetitive transcranial magnetic stimulation (rTMS) applied to the left dorsolateral prefrontal cortex (DLPFC) has the potential to improve cognitive functioning. We analyzed the effects of 10-Hz rTMS to the left DLPFC on cognitive deficits in ...

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