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Regioselectivity of the alkylation of S-substituted 1,2,4-triazoles with dihaloalkanes

Boraei, Ahmed T. A. ; El Ashry, El Sayed H. ; Duerkop, Axel


Background: 1,2,4-Triazole3-thiones are good scaffolds for preparation of new lead compounds. Their derivatives attracted the attention of chemists due to their wide spectrum of biological activities. Alkylsulfanyl-1,2,4-triazoles have three nucleophilic sites (nitrogens) ready for reaction with electrophiles. Herein, new regioselective isomers were synthesized by the reaction of ...


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