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Induction of exportin-5 expression during melanoma development supports the cellular behavior of human malignant melanoma cells

Ott, Corinna Anna ; Linck, Lisa ; Kremmer, Elisabeth ; Meister, Gunter ; Bosserhoff, Anja Katrin


Regulation of gene expression via microRNAs is known to promote the development of many types of cancer. In melanoma, miRNAs are globally up-regulated, and alterations of miRNA-processing enzymes have already been identified. However, mis-regulation of miRNA transport has not been analyzed in melanoma yet. We hypothesized that alterations in miRNA transport disrupt miRNA processing. Therefore, we ...


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