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α-MSH modulates cell adhesion and inflammatory responses of synovial fibroblasts from osteoarthritis patients

Böhm, Markus ; Apel, Mara ; Lowin, Torsten ; Lorenz, Julia ; Jenei-Lanzl, Zsuzsa ; Capellino, Silvia ; Dosoki, Heba ; Luger, Thomas A. ; Straub, Rainer H. ; Grässel, Susanne



Abstract

Introduction: The synovium is a target for neuropeptides. Melanocortins have attained particular attention as they elicit antiinflammatory effects. Although synovial fluid from patients with rheumatic diseases contains alpha-melanocyte-stimulating hormone (alpha-MSH) it is unknown whether synovial fibroblasts generate alpha-MSH and respond to melanocortins. Methods: Synovial tissue was obtained ...

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