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Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes

Pylypenko, Olena ; Welz, Tobias ; Tittel, Janine ; Kollmar, Martin ; Chardon, Florian ; Malherbe, Gilles ; Weiss, Sabine ; Michel, Carina Ida Luise ; Samol-Wolf, Annette ; Grasskamp, Andreas Till ; Hume, Alistair ; Goud, Bruno ; Baron, Bruno ; England, Patrick ; Titus, Margaret A. ; Schwille, Petra ; Weidemann, Thomas ; Houdusse, Anne ; Kerkhoff, Eugen


There is growing evidence for a coupling of actin assembly and myosin motor activity in cells. However, mechanisms for recruitment of actin nucleators and motors on specific membrane compartments remain unclear. Here we report how Spir actin nucleators and myosin V motors coordinate their specific membrane recruitment. The myosin V globular tail domain (MyoV-GTD) interacts directly with an ...


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