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Risperidone-induced extrapyramidal side effects

Schoretsanitis, Georgios ; Haen, Ekkehard ; Hiemke, Christoph ; Gründer, Gerhard ; Stegmann, Benedikt ; Schruers, Koen R.J. ; Veselinovic, Tanja ; Lammertz, Sarah E. ; Paulzen, Michael


Antipsychotic drugs can induce various undesirable adverse motor reactions, such as extrapyramidal side effects (EPS). A widely accepted pharmacodynamic mechanism underlying EPS includes an increase in striatal D2-receptor occupancy. However, less is known about the pharmacokinetic background of EPS. The aim of this study was to analyze in-vivo possible pharmacokinetic patterns underlying ...


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