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Argonaute Family Protein Expression in Normal Tissue and Cancer Entities

Pfeffer, Sebastien ; Völler, Daniel ; Linck, Lisa ; Bruckmann, Astrid ; Hauptmann, Judith ; Deutzmann, Rainer ; Meister, Gunter ; Bosserhoff, Anja Katrin



Abstract

Themembers of the Argonaute (AGO) protein family are key players inmiRNA-guided gene silencing. They enable the interaction between small RNAs and their respective target mRNA (s) and support the catalytic destruction of the gene transcript or recruit additional proteins for downstream gene silencing. The human AGO family consists of four AGO proteins (AGO1-AGO4), but only AGO2 harbors nuclease ...

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