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Conformational Substates of Amyloidogenic hIAPP Revealed by High Pressure NMR Spectroscopy

Erlach, Markus Beck ; Kalbitzer, Hans Robert ; Winter, Roland ; Kremer, Werner



Abstract

The islet amyloid polypeptide (IAPP) is a peptide hormone that is secreted by pancreatic beta cells along with glucagon and insulin. The development of type-2 diabetes mellitus (T2DM) is accompanied by aggregation and amyloid deposits of IAPP. Here we report pressure-induced changes of NMR chemical shifts for the elucidation of conformational substates of IAPP in bulk solution. Comparison with a ...

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