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Brain CRF-binding protein modulates aspects of maternal behavior under stressful conditions and supports a hypo-anxious state in lactating rats

Klampfl, Stefanie M. ; Schramm, Milena M. ; Stinnett, Gwen S. ; Bayerl, Doris S. ; Seasholtz, Audrey F. ; Bosch, Oliver J.



Abstract

Reduced corticotropin-releasing factor (CRF) receptor activation in the postpartum period is essential for adequate maternal behavior. One of the factors contributing to this hypo-activity might be the CRF-binding protein (CRF-BP), which likely reduces the availability of free extracellular CRF/urocortin 1. Here, we investigated behavioral effects of acute CRF-BP inhibition using 5 mu g of ...

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