Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade

Wang, Chunmei ; Che, Li ; Hu, Junjie ; Zhang, Shanshan ; Jiang, Lijie ; Latte, Gavinella

; Demartis, Maria I. ; Tao, Junyan ; Gui, Bing ; Pilo, Maria G. ; Ribback, Silvia ; Dombrowski, Frank ; Evert, Matthias ; Calvisi, Diego F. ; Chen, Xin

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Background & AimsActivating mutations of PIK3CA occur in various tumour types, including human hepatocellular carcinoma. The mechanisms whereby PIK3CA contributes to hepatocarcinogenesis remain poorly understood. MethodsPIK3CA mutants H1047R or E545K were hydrodynamically transfected, either alone or in combination with NRasV12 or c-Met genes, in the mouse liver. ResultsOverexpression of H1047R ...