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The Lupus Autoantigen La Prevents Mis-channeling of tRNA Fragments into the Human MicroRNA Pathway

Hasler, Daniele ; Lehmann, Gerhard ; Murakawa, Yasuhiro ; Klironomos, Filippos ; Jakob, Leonhard ; Grässer, Friedrich A. ; Rajewsky, Nikolaus ; Landthaler, Markus ; Meister, Gunter



Abstract

The Lupus autoantigen La is an RNA-binding protein that stabilizes RNA polymerase III (Pol III) transcripts and supports RNA folding and has in addition been implicated in the mammalian microRNA (miRNA) pathway. Here, we have analyzed effects of La depletion on Argonaute (Ago)-bound small RNAs in human cells. We find that in the absence of La, distinct tRNA fragments are loaded into Ago proteins. ...

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