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Cutoff Suppresses RNA Polymerase II Termination to Ensure Expression of piRNA Precursors

Chen, Yung-Chia Ariel ; Stuwe, Evelyn ; Luo, Yicheng ; Ninova, Maria ; Le Thomas, Adrien ; Rozhavskaya, Ekaterina ; Li, Sisi ; Vempati, Sivani ; Laver, John D. ; Patel, Dinshaw J. ; Smibert, Craig A. ; Lipshitz, Howard D. ; Fejes Toth, Katalin ; Aravin, Alexei A.



Abstract

Small non-coding RNAs called piRNAs serve as guides for an adaptable immune system that represses transposable elements in germ cells of Metazoa. In Drosophila the RDC complex, composed of Rhino, Deadlock and Cutoff (Cuff) bind chromatin of dual-strand piRNA clusters, special genomic regions, which encode piRNA precursors. The RDC complex is required for transcription of piRNA precursors, though ...

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