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Orphan Nuclear Receptor NR4A1 Binds a Novel Protein Interaction Site on Anti-apoptotic B Cell Lymphoma Gene 2 Family Proteins

Godoi, Paulo H. C. ; Wilkie-Grantham, Rachel P. ; Hishiki, Asami ; Sano, Renata ; Matsuzawa, Yasuko ; Yanagi, Hiroko ; Munte, Claudia E. ; Chen, Ya ; Yao, Yong ; Marassi, Francesca M. ; Kalbitzer, Hans R. ; Matsuzawa, Shu-ichi ; Reed, John C.



Abstract

B cell lymphoma gene 2 (Bcl-2) family proteins are key regulators of programmed cell death and important targets for drug discovery. Pro-apoptotic and anti-apoptotic Bcl-2 family proteins reciprocally modulate their activities in large part through protein interactions involving a motif known as BH3 (Bcl-2 homology 3). Nur77 is an orphan member of the nuclear receptor family that lacks a BH3 ...

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