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Transforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in Hepatocytes

Chen, Simeng ; Feng, Teng ; Vujić Spasić, Maja ; Altamura, Sandro ; Breitkopf-Heinlein, Katja ; Altenöder, Jutta ; Weiss, Thomas S. ; Dooley, Steven ; Muckenthaler, Martina U.



Abstract

The hepatic hormone hepcidin is the master regulator of systemic iron homeostasis. Its expression level is adjusted to alterations in iron levels, inflammatory cues, and iron requirements for erythropoiesis. Bone morphogenetic protein 6 (BMP6) contributes to the iron-dependent control of hepcidin. In addition, TGF-beta 1 may stimulate hepcidin mRNA expression in murine hepatocytes and human ...

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