KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

Article

Schumann, Gunter, Liu, Chunyu , O’Reilly, Paul , Gao, He, Song, Parkyong, Xu, Bing, Ruggeri, Barbara , Amin, Najaf , Jia, Tianye, Preis, Sarah, Segura Lepe, Marcelo, Akira, Shizuo, Barbieri, Caterina, Baumeister, Sebastian, Cauchi, Stephane, Clarke, Toni-Kim, Enroth, Stefan, Fischer, Krista, Hällfors, Jenni, Harris, Sarah E., Hieber, Saskia, Hofer, Edith, Hottenga, Jouke-Jan, Johansson, Åsa , Joshi, Peter K., Kaartinen, Niina, Laitinen, Jaana, Lemaitre, Rozenn, Loukola, Anu , Luan, Jian’an, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Manichaikul, Ani, Mbarek, Hamdi , Milaneschi, Yuri, Moayyeri, Alireza, Mukamal, Kenneth, Nelson, Christopher, Nettleton, Jennifer, Partinen, Eemil, Rawal, Rajesh, Robino, Antonietta, Rose, Lynda, Sala, Cinzia, Satoh, Takashi, Schmidt, Reinhold, Schraut, Katharina, Scott, Robert, Smith, Albert Vernon, Starr, John M., Teumer, Alexander, Trompet, Stella, Uitterlinden, André G., Venturini, Cristina, Vergnaud, Anne-Claire, Verweij, Niek, Vitart, Veronique, Vuckovic, Dragana, Wedenoja, Juho , Yengo, Loic , Yu, Bing, Zhang, Weihua, Zhao, Jing Hua, Boomsma, Dorret I., Chambers, John, Chasman, Daniel I., Toniolo, Daniela, de Geus, Eco , Deary, Ian , Eriksson, Johan G., Esko, Tõnu, Eulenburg, Volker , Franco, Oscar H., Froguel, Philippe, Gieger, Christian, Grabe, Hans J., Gudnason, Vilmundur, Gyllensten, Ulf, Harris, Tamara B., Hartikainen, Anna-Liisa, Heath, Andrew C., Hocking, Lynne, Hofman, Albert, Huth, Cornelia , Jarvelin, Marjo-Riitta, Jukema, J. Wouter, Kaprio, Jaakko , Kooner, Jaspal S., Kutalik, Zoltan, Lahti, Jari , Langenberg, Claudia, Lehtimäki, Terho, Liu, Yongmei , Madden, Pamela A. F., Martin, Nicholas, Morrison, Alanna , Penninx, Brenda, Pirastu, Nicola, Psaty, Bruce, Raitakari, Olli, Ridker, Paul, Rose, Richard, Rotter, Jerome I., Samani, Nilesh J., Schmidt, Helena, Spector, Tim D., Stott, David, Strachan, David, Tzoulaki, Ioanna, van der Harst, Pim, van Duijn, Cornelia M., Marques-Vidal, Pedro, Vollenweider, Peter, Wareham, Nicholas J., Whitfield, John B., Wilson, James, Wolffenbuttel, Bruce, Bakalkin, Georgy, Evangelou, Evangelos, Liu, Yun , Rice, Kenneth M., Desrivières, Sylvane , Kliewer, Steven A., Mangelsdorf, David J., Müller, Christian P., Levy, Daniel and Elliott, Paul (2016) KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. Proceedings of the National Academy of Sciences 113 (50), pp. 14372-14377.

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Details

Item type	Article
Journal or Publication Title	Proceedings of the National Academy of Sciences
Publisher	NATL ACAD SCIENCES
Place of Publication	WASHINGTON
Volume	113
Number of Issue or Book Chapter	50
Page Range	pp. 14372-14377
Date	2016
Date of publication	17 Mar 2020 11:47
Institutions	Medicine > Institut für Epidemiologie und Präventivmedizin
Identification Number	Value Type 10.1073/pnas.1611243113 DOI
Keywords	GENOME-WIDE ASSOCIATION; CONSUMPTION; DISEASE; ACTIVATION; DEPENDENCE; SWEET; LIVER; HEART; MICE; alcohol consumption; human; beta-Klotho; FGF21; mouse model
Dewey Decimal Classification	600 Technology > 610 Medical sciences Medicine
Status	Published
Refereed	Yes, this version has been refereed
Created at the University of Regensburg	Yes
Item ID	42715

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