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Direct observation of a deoxyadenosyl radical in an active enzyme environment

Heidinger, Lorenz ; Kneuttinger, Andrea C. ; Kashiwazaki, Gengo ; Weber, Stefan ; Carell, Thomas ; Schleicher, Erik


5'-deoxyadenosyl radicals have been proposed as the first common intermediate in the molecular reaction mechanism of the family of radical S-adenosyl-L-methionine (SAM) enzymes. However, this radical species has not yet been directly observed in a catalytically active enzyme environment. In a reduced and SAM-containing C140A mutant of the spore photoproduct lyase from Geobacillus ...


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