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P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells

Kraus, Andre ; Grampp, Steffen ; Goppelt-Struebe, Margarete ; Schreiber, Rainer ; Kunzelmann, Karl ; Peters, Dorien J.M. ; Leipziger, Jens ; Schley, Gunnar ; Schödel, Johannes ; Eckardt, Kai-Uwe ; Buchholz, Bjoern



Abstract

Polycystic kidney diseases are characterized by numerous renal cysts that continuously enlarge resulting in compression of intact nephrons and tissue hypoxia. Recently, we have shown that hypoxia-inducible factor (HIF)-1 alpha promotes secretion-dependent cyst expansion, presumably by transcriptional regulation of proteins that are involved in calcium-activated chloride secretion. Here, we report ...

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