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All-trans retinoic acid as adjunct to intensive treatment in younger adult patients with acute myeloid leukemia: results of the randomized AMLSG 07-04 study

Schlenk, Richard F. ; Lübbert, Michael ; Benner, Axel ; Lamparter, Alexander ; Krauter, Jürgen ; Herr, Wolfgang ; Martin, Hans ; Salih, Helmut R. ; Kündgen, Andrea ; Horst, Heinz-A. ; Brossart, Peter ; Götze, Katharina ; Nachbaur, David ; Wattad, Mohammed ; Köhne, Claus-Henning ; Fiedler, Walter ; Bentz, Martin ; Wulf, Gerald ; Held, Gerhard ; Hertenstein, Bernd ; Salwender, Hans ; Gaidzik, Verena I ; Schlegelberger, Brigitte ; Weber, Daniela ; Döhner, Konstanze ; Ganser, Arnold ; Döhner, Hartmut



Abstract

The aim of this clinical trial was to evaluate the impact of all-trans retinoic acid (ATRA) in combination with chemotherapy and to assess the NPM1 status as biomarker for ATRA therapy in younger adult patients (18-60 years) with acute myeloid leukemia (AML). Patients were randomized for intensive chemotherapy with or without open-label ATRA (45 mg/m(2), days 6-8; 15 mg/m(2), days 9-21). Two ...

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