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Corticotropin-releasing hormone induces depression-like changes of sleep electroencephalogram in healthy women

Schüssler, P. ; Kluge, M. ; Gamringer, W. ; Wetter, T. C. ; Yassouridis, A. ; Uhr, M. ; Rupprecht, R. ; Steiger, A.



Abstract

We reported previously that repetitive intravenous injections of corticotropin-releasing hormone (CRH) around sleep onset prompt depression-like changes in certain sleep and endocrine activity parameters (e.g. decrease of slow-wave sleep during the second half of the night, blunted growth hormone peak, elevated cortisol concentration during the first half of the night). Furthermore a sexual ...

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