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oxLDL and eLDL Induced Membrane Microdomains in Human Macrophages

Cowart, Ashley ; Wallner, Stefan ; Grandl, Margot ; Liebisch, Gerhard ; Peer, Markus ; Orsó, Evelyn ; Sigrüner, Alexander ; Sobota, Andrzej ; Schmitz, Gerd



Abstract

Background Extravasation of macrophages and formation of lipid-laden foam cells are key events in the development and progression of atherosclerosis. The degradation of atherogenic lipoproteins subsequently leads to alterations in cellular lipid metabolism that influence inflammatory signaling. Especially sphingolipids and ceramides are known to be involved in these processes. We therefore ...

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