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Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma

Elliott, Michael H. ; Ashpole, Nicole E. ; Gu, Xiaowu ; Herrnberger, Leonie ; McClellan, Mark E. ; Griffith, Gina L. ; Reagan, Alaina M. ; Boyce, Timothy M. ; Tanito, Masaki ; Tamm, Ernst R. ; Stamer, W. Daniel



Abstract

Polymorphisms in the CAV1/2 genes that encode signature proteins of caveolae are associated with glaucoma, the second leading cause of blindness worldwide, and with its major risk factor, intraocular pressure (IOP). We hypothesized that caveolin-1 (Cav-1) participates in IOP maintenance via modulation of aqueous humor drainage from the eye. We localize caveolae proteins to human and murine ...

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