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Serologic Anti-GP2 Antibodies Are Associated with Genetic Polymorphisms, Fibrostenosis, and Need for Surgical Resection in Crohnʼs Disease

Degenhardt, Frauke ; Dirmeier, Andrea ; Lopez, Rocio ; Lang, Sylvia ; Kunst, Claudia ; Roggenbuck, Dirk ; Reinhold, Dirk ; Szymczak, Silke ; Rogler, Gerhard ; Klebl, Frank ; Franke, Andre ; Rieder, Florian



Abstract

Background:The presentation of Crohn's disease (CD) is heterogeneous and often leads to serious complications and need for surgery. We tested serum anti-zymogen granule glycoprotein 2 (GP2) antibodies, including its novel isoform alpha, for association with genetic variants, diagnosis, disease stratification, and prediction of CD courses in a combined cross-sectional and cohort ...

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