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Expression of the p53 Inhibitors MDM2 and MDM4 as Outcome Predictor in Muscle-invasive Bladder Cancer

KRIEGMAIR, MAXIMILIAN CHRISTIAN ; BALK, MATTHIAS ; WIRTZ, RALPH ; STEIDLER, ANNETTE ; WEIS, CLEO-ARON ; BREYER, JOHANNES ; HARTMANN, ARNDT ; BOLENZ, CHRISTIAN ; ERBEN, PHILIPP



Abstract

Aim: To evaluate the prognostic role of the p53-upstream inhibitors MDM2, MDM4 and its splice variant MDM4-S in patients undergoing radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). Materials and Methods: mRNA Expression levels of MDM2, MDM4 and MDM4-S were assessed by quantitative real-time polymerase chain reaction (qRT-PCR) in 75 RC samples. Logistic regression analyses ...

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