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Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits

Teumer, Alexander ; Qi, Qibin ; Nethander, Maria ; Aschard, Hugues ; Bandinelli, Stefania ; Beekman, Marian ; Berndt, Sonja I. ; Bidlingmaier, Martin ; Broer, Linda ; Cappola, Anne ; Ceda, Gian Paolo ; Chanock, Stephen ; Chen, Ming-Huei ; Chen, Tai C. ; Chen, Yii-Der Ida ; Chung, Jonathan ; Del Greco Miglianico, Fabiola ; Eriksson, Joel ; Ferrucci, Luigi ; Friedrich, Nele ; Gnewuch, Carsten ; Goodarzi, Mark O. ; Grarup, Niels ; Guo, Tingwei ; Hammer, Elke ; Hayes, Richard B. ; Hicks, Andrew A. ; Hofman, Albert ; Houwing-Duistermaat, Jeanine J. ; Hu, Frank ; Hunter, David J. ; Husemoen, Lise L. ; Isaacs, Aaron ; Jacobs, Kevin B. ; Janssen, Joop A. M. J. L. ; Jansson, John-Olov ; Jehmlich, Nico ; Johnson, Simon ; Juul, Anders ; Karlsson, Magnus ; Kilpelainen, Tuomas O. ; Kovacs, Peter ; Kraft, Peter ; Li, Chao ; Linneberg, Allan ; Liu, Yongmei ; Loos, Ruth J. F. ; Lorentzon, Mattias ; Lu, Yingchang ; Maggio, Marcello ; Magi, Reedik ; Meigs, James ; Mellström, Dan ; Nauck, Matthias ; Newman, Anne B. ; Pollak, Michael N. ; Pramstaller, Peter P. ; Prokopenko, Inga ; Psaty, Bruce M. ; Reincke, Martin ; Rimm, Eric B. ; Rotter, Jerome I. ; Saint Pierre, Aude ; Schurmann, Claudia ; Seshadri, Sudha ; Sjögren, Klara ; Slagboom, P. Eline ; Strickler, Howard D. ; Stumvoll, Michael ; Suh, Yousin ; Sun, Qi ; Zhang, Cuilin ; Svensson, Johan ; Tanaka, Toshiko ; Tare, Archana ; Tönjes, Anke ; Uh, Hae-Won ; van Duijn, Cornelia M. ; van Heemst, Diana ; Vandenput, Liesbeth ; Vasan, Ramachandran S. ; Völker, Uwe ; Willems, Sara M. ; Ohlsson, Claes ; Wallaschofski, Henri ; Kaplan, Robert C.



Abstract

The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Through genomewide association study of up to 30884 adults of European ancestry from 21 studies, ...

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