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Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

Godoy, Patricio ; Widera, Agata ; Schmidt-Heck, Wolfgang ; Campos, Gisela ; Meyer, Christoph ; Cadenas, Cristina ; Reif, Raymond ; Stöber, Regina ; Hammad, Seddik ; Pütter, Larissa ; Gianmoena, Kathrin ; Marchan, Rosemarie ; Ghallab, Ahmed ; Edlund, Karolina ; Nüssler, Andreas ; Thasler, Wolfgang E. ; Damm, Georg ; Seehofer, Daniel ; Weiss, Thomas S. ; Dirsch, Olaf ; Dahmen, Uta ; Gebhardt, Rolf ; Chaudhari, Umesh ; Meganathan, Kesavan ; Sachinidis, Agapios ; Kelm, Jens ; Hofmann, Ute ; Zahedi, René P. ; Guthke, Reinhard ; Blüthgen, Nils ; Dooley, Steven ; Hengstler, Jan G.


It is well known that isolation and cultivation of primary hepatocytes cause major gene expression alterations. In the present genome-wide, time-resolved study of cultivated human and mouse hepatocytes, we made the observation that expression changes in culture strongly resemble alterations in liver diseases. Hepatocytes of both species were cultivated in collagen sandwich and in monolayer ...


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