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Cl− channels in apoptosis

Wanitchakool, Podchanart ; Ousingsawat, Jiraporn ; Sirianant, Lalida ; MacAulay, Nanna ; Schreiber, Rainer ; Kunzelmann, Karl



Abstract

A remarkable feature of apoptosis is the initial massive cell shrinkage, which requires opening of ion channels to allow release of K+, Cl-, and organic osmolytes to drive osmotic water movement and cell shrinkage. This article focuses on the role of the Cl- channels LRRC8, TMEM16/anoctamin, and cystic fibrosis transmembrane conductance regulator (CFTR) in cellular apoptosis. LRRC8A-E has been ...

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