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Relationship between TMEM16A/anoctamin 1 and LRRC8A

Benedetto, Roberta ; Sirianant, Lalida ; Pankonien, Ines ; Wanitchakool, Podchanart ; Ousingsawat, Jiraporn ; Cabrita, Ines ; Schreiber, Rainer ; Amaral, Margarida ; Kunzelmann, Karl



Abstract

TMEM16A/anoctamin 1/ANO1 and VRAC/LRRC8 are independent chloride channels activated either by increase in intracellular Ca2+ or cell swelling, respectively. In previous studies, we observed overlapping properties for both types of channels. (i) TMEM16A/ANO1 and LRRC8 are inhibited by identical compounds, (ii) the volume-regulated anion channel VRAC requires compartmentalized Ca2+ increase to be ...

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