Go to content
UR Home

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

Liu, Chunyu ; Kraja, Aldi T. ; Smith, Jennifer A. ; Brody, Jennifer A. ; Franceschini, Nora ; Bis, Joshua C. ; Rice, Kenneth ; Morrison, Alanna C. ; Lu, Yingchang ; Weiss, Stefan ; Guo, Xiuqing ; Palmas, Walter ; Martin, Lisa W. ; Chen, Yii-Der Ida ; Surendran, Praveen ; Drenos, Fotios ; Cook, James P. ; Auer, Paul L. ; Chu, Audrey Y. ; Giri, Ayush ; Zhao, Wei ; Jakobsdottir, Johanna ; Lin, Li-An ; Stafford, Jeanette M. ; Amin, Najaf ; Mei, Hao ; Yao, Jie ; Voorman, Arend ; Larson, Martin G. ; Grove, Megan L. ; Smith, Albert V. ; Hwang, Shih-Jen ; Chen, Han ; Huan, Tianxiao ; Kosova, Gulum ; Stitziel, Nathan O. ; Kathiresan, Sekar ; Samani, Nilesh ; Schunkert, Heribert ; Deloukas, Panos ; Li, Man ; Fuchsberger, Christian ; Pattaro, Cristian ; Gorski, Mathias ; Kooperberg, Charles ; Papanicolaou, George J. ; Rossouw, Jacques E. ; Faul, Jessica D. ; Kardia, Sharon L. R. ; Bouchard, Claude ; Raffel, Leslie J. ; Uitterlinden, André G. ; Franco, Oscar H. ; Vasan, Ramachandran S. ; O'Donnell, Christopher J. ; Taylor, Kent D. ; Liu, Kiang ; Bottinger, Erwin P. ; Gottesman, Omri ; Daw, E. Warwick ; Giulianini, Franco ; Ganesh, Santhi ; Salfati, Elias ; Harris, Tamara B. ; Launer, Lenore J. ; Dörr, Marcus ; Felix, Stephan B. ; Rettig, Rainer ; Völzke, Henry ; Kim, Eric ; Lee, Wen-Jane ; Lee, I.-Te ; Sheu, Wayne H.-H. ; Tsosie, Krystal S. ; Edwards, Digna R. Velez ; Liu, Yongmei ; Correa, Adolfo ; Weir, David R. ; Völker, Uwe ; Ridker, Paul M. ; Boerwinkle, Eric ; Gudnason, Vilmundur ; Reiner, Alexander P. ; van Duijn, Cornelia M. ; Borecki, Ingrid B. ; Edwards, Todd L. ; Chakravarti, Aravinda ; Rotter, Jerome I. ; Psaty, Bruce M. ; Loos, Ruth J. F. ; Fornage, Myriam ; Ehret, Georg B. ; Newton-Cheh, Christopher ; Levy, Daniel ; Chasman, Daniel I.



Abstract

Meta-analyses of association results for blood pressure using exome-centric single-variant and gene-based tests identified 31 new loci in a discovery stage among 146,562 individuals, with follow-up and meta-analysis in 180,726 additional individuals (total n = 327,288). These blood pressure-associated loci are enriched for known variants for cardiometabolic traits. Associations were also observed ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons