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Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

Liu, Chunyu ; Kraja, Aldi T ; Smith, Jennifer A ; Brody, Jennifer A ; Franceschini, Nora ; Bis, Joshua C ; Rice, Kenneth ; Morrison, Alanna C ; Lu, Yingchang ; Weiss, Stefan ; Guo, Xiuqing ; Palmas, Walter ; Martin, Lisa W ; Chen, Yii-Der Ida ; Surendran, Praveen ; Drenos, Fotios ; Cook, James P ; Auer, Paul L ; Chu, Audrey Y ; Giri, Ayush ; Zhao, Wei ; Jakobsdottir, Johanna ; Lin, Li-An ; Stafford, Jeanette M ; Amin, Najaf ; Mei, Hao ; Yao, Jie ; Voorman, Arend ; Larson, Martin G ; Grove, Megan L ; Smith, Albert V ; Hwang, Shih-Jen ; Chen, Han ; Huan, Tianxiao ; Kosova, Gulum ; Stitziel, Nathan O ; Kathiresan, Sekar ; Samani, Nilesh ; Schunkert, Heribert ; Deloukas, Panos ; Li, Man ; Fuchsberger, Christian ; Pattaro, Cristian ; Gorski, Mathias ; Kooperberg, Charles ; Papanicolaou, George J ; Rossouw, Jacques E ; Faul, Jessica D ; Kardia, Sharon L R ; Bouchard, Claude ; Raffel, Leslie J ; Uitterlinden, André G ; Franco, Oscar H ; Vasan, Ramachandran S ; O'Donnell, Christopher J ; Taylor, Kent D ; Liu, Kiang ; Bottinger, Erwin P ; Gottesman, Omri ; Daw, E Warwick ; Giulianini, Franco ; Ganesh, Santhi ; Salfati, Elias ; Harris, Tamara B ; Launer, Lenore J ; Dörr, Marcus ; Felix, Stephan B ; Rettig, Rainer ; Völzke, Henry ; Kim, Eric ; Lee, Wen-Jane ; Lee, I-Te ; Sheu, Wayne H-H ; Tsosie, Krystal S ; Edwards, Digna R Velez ; Liu, Yongmei ; Correa, Adolfo ; Weir, David R ; Völker, Uwe ; Ridker, Paul M ; Boerwinkle, Eric ; Gudnason, Vilmundur ; Reiner, Alexander P ; van Duijn, Cornelia M ; Borecki, Ingrid B ; Edwards, Todd L ; Chakravarti, Aravinda ; Rotter, Jerome I ; Psaty, Bruce M ; Loos, Ruth J F ; Fornage, Myriam ; Ehret, Georg B ; Newton-Cheh, Christopher ; Levy, Daniel ; Chasman, Daniel I



Abstract

Meta-analyses of association results for blood pressure using exome-centric single-variant and gene-based tests identified 31 new loci in a discovery stage among 146,562 individuals, with follow-up and meta-analysis in 180,726 additional individuals (total n = 327,288). These blood pressure-associated loci are enriched for known variants for cardiometabolic traits. Associations were also observed ...

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