Item type: | Article | ||||
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Journal or Publication Title: | Nature Genetics | ||||
Publisher: | Nature | ||||
Place of Publication: | NEW YORK | ||||
Volume: | 48 | ||||
Number of Issue or Book Chapter: | 10 | ||||
Page Range: | pp. 1162-1170 | ||||
Date: | 2016 | ||||
Institutions: | Medicine > Institut für Epidemiologie und Präventivmedizin | ||||
Identification Number: |
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Keywords: | GENOME-WIDE ASSOCIATION; LIPOPROTEIN-LIPASE GENE; NATRIURETIC PEPTIDE RECEPTOR; SUSCEPTIBILITY LOCI; MONOGENIC FORMS; CENTRIC ARRAY; HYPERTENSION; DISEASE; EXPRESSION; RISK; | ||||
Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
Status: | Published | ||||
Refereed: | Yes, this version has been refereed | ||||
Created at the University of Regensburg: | Yes | ||||
Item ID: | 42991 |
Abstract
Meta-analyses of association results for blood pressure using exome-centric single-variant and gene-based tests identified 31 new loci in a discovery stage among 146,562 individuals, with follow-up and meta-analysis in 180,726 additional individuals (total n = 327,288). These blood pressure-associated loci are enriched for known variants for cardiometabolic traits. Associations were also observed ...
Abstract
Meta-analyses of association results for blood pressure using exome-centric single-variant and gene-based tests identified 31 new loci in a discovery stage among 146,562 individuals, with follow-up and meta-analysis in 180,726 additional individuals (total n = 327,288). These blood pressure-associated loci are enriched for known variants for cardiometabolic traits. Associations were also observed for the aggregation of rare and low-frequency missense variants in three genes, NPR1, DBH, and PTPMT1. In addition, blood pressure associations at 39 previously reported loci were confirmed. The identified variants implicate biological pathways related to cardiometabolic traits, vascular function, and development. Several new variants are inferred to have roles in transcription or as hubs in protein-protein interaction networks. Genetic risk scores constructed from the identified variants were strongly associated with coronary disease and myocardial infarction. This large collection of blood pressure-associated loci suggests new therapeutic strategies for hypertension, emphasizing a link with cardiometabolic risk.
Metadata last modified: 18 Feb 2021 11:19