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Anakoinosis: Correcting Aberrant Homeostasis of Cancer Tissue—Going Beyond Apoptosis Induction

Heudobler, Daniel ; Lüke, Florian ; Vogelhuber, Martin ; Klobuch, Sebastian ; Pukrop, Tobias ; Herr, Wolfgang ; Gerner, Christopher ; Pantziarka, Pan ; Ghibelli, Lina ; Reichle, Albrecht
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Date of publication of this fulltext: 30 Mar 2020 15:47


Abstract

The current approach to systemic therapy for metastatic cancer is aimed predominantly at inducing apoptosis of cancer cells by blocking tumor-promoting signaling pathways or by eradicating cell compartments within the tumor. In contrast, a systems view of therapy primarily considers the communication protocols that exist at multiple levels within the tumor complex, and the role of key regulators ...

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