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Three-dimensional self-assembling nanofiber matrix rejuvenates aged/degenerative human tendon stem/progenitor cells

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Yin, Heyong ; Strunz, Franziska ; Yan, Zexing ; Lu, Jiaju ; Brochhausen, Christoph ; Kiderlen, Stefanie ; Clausen-Schaumann, Hauke ; Wang, Xiumei ; Gomes, Manuela E. ; Alt, Volker ; Docheva, Denitsa
Date of publication of this fulltext: 06 May 2020 13:06


The poor healing capacity of tendons is known to worsen in the elderly. During tendon aging and degeneration, endogenous human tendon stem/progenitor cells (hTSPCs) experience profound pathological changes. Here, we explored a rejuvenation strategy for hTSPCs derived from aged/degenerated Achilles tendons (A-TSPCs) by providing three-dimensional (3D) nanofiber hydrogels and comparing them to ...


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