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Aged Tendon Stem/Progenitor Cells Are Less Competent to Form 3D Tendon Organoids Due to Cell Autonomous and Matrix Production Deficits

URN to cite this document:
urn:nbn:de:bvb:355-epub-431265
Yan, Zexing ; Yin, Heyong ; Brochhausen, Christoph ; Pfeifer, Christian G. ; Alt, Volker ; Docheva, Denitsa
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Date of publication of this fulltext: 06 May 2020 09:44


Abstract

Tendons are dense connective tissues, which are critical for the integrity and function of our musculoskeletal system. During tendon aging and degeneration, tendon stem/progenitor cells (TSPCs) experience profound phenotypic changes with declined cellular functions that can be linked to the known increase in complications during tendon healing process in elderly patients. Tissue engineering is a ...

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