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Major Depressive Disorder is Associated with Impaired Mitochondrial Function in Skin Fibroblasts

Kuffner, Kerstin ; Triebelhorn, Julian ; Meindl, Katrin ; Benner, Christoph ; Manook, André ; Sudria-Lopez, Daniel ; Siebert, Ramona ; Nothdurfter, Caroline ; Baghai, Thomas C. ; Drexler, Konstantin ; Berneburg, Mark ; Rupprecht, Rainer ; Milenkovic, Vladimir M. ; Wetzel, Christian H.
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Date of publication of this fulltext: 12 May 2020 12:07


Abstract

Mitochondrial malfunction is supposed to be involved in the etiology and pathology of major depressive disorder (MDD). Here, we aimed to identify and characterize the molecular pathomechanisms related to mitochondrial dysfunction in adult human skin fibroblasts, which were derived from MDD patients or non-depressive control subjects. We found that MDD fibroblasts showed significantly impaired ...

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