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Methodical aspects of urinary metabolomics by liquid chromatography-mass spectrometry

URN to cite this document:
urn:nbn:de:bvb:355-epub-432196
Vogl, Franziska C.
Date of publication of this fulltext: 10 Jun 2020 11:14


Abstract (English)

With recent instrumental improvements, untargeted high-resolution liquid chromatography mass spectrometry (LC-MS) has been increasingly applied to the analysis of complex biological matrices such as urine. The latter is a preferred matrix in large scale metabolomics studies, because it can be obtained non-invasively in sufficient quantities. However, the widely varying concentrations of urine ...

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Translation of the abstract (German)

Auf Grund von instrumentellen Verbesserungen hat die hochauflösende, nicht zielgerichtete Flüssigchromatographie - Massenspektrometrie (LC-MS Finger-printing-Analyse) rasant an Bedeutung in der Analyse von komplexen biologi-schen Matrices wie Urin gewonnen. Urin ist eine sehr interessante Proben-matrix für große Kohorten-Studien, da sie nicht invasiv und in ausreichenden Mengen gesammelt werden ...

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