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Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans

Schlosser, P. ; Li, Y. ; Sekula, P. ; Raffler, J. ; Grundner-Culemann, F. ; Pietzner, M. ; Cheng, Y. ; Wuttke, M. ; Steinbrenner, I. ; Schultheiss, U. T. ; Kotsis, F. ; Kacprowski, T. ; Forer, L. ; Hausknecht, B. ; Ekici, A. B. ; Nauck, M. ; Voelker, U. ; Walz, G. ; Oefner, Peter J. ; Kronenberg, F. ; Mohney, R. P. ; K?ttgen, M. ; Suhre, K. ; Eckardt, K. U. ; Kastenmüller, G. ; Koettgen, Anna



Abstract

The kidneys integrate information from continuous systemic processes related to the absorption, distribution, metabolism and excretion (ADME) of metabolites. To identify underlying molecular mechanisms, we performed genome-wide association studies of the urinary concentrations of 1,172 metabolites among 1,627 patients with reduced kidney function. The 240 unique metabolite–locus associations ...

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