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Acquired resistance to DZNep-mediated apoptosis is associated with copy number gains of AHCY in a B-cell lymphoma model

URN to cite this document:
urn:nbn:de:bvb:355-epub-432224
Akpa, C. A. ; Kleo, K. ; Oker, E. ; Tomaszewski, N. ; Messerschmidt, C. ; L?pez, C. ; Wagener, R. ; Oehl-Huber, K. ; Dettmer, Katja ; Schoeler, A. ; Lenze, D. ; Oefner, Peter J. ; Beule, D. ; Siebert, R. ; Capper, D. ; Dimitrova, L. ; Hummel, M.
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Date of publication of this fulltext: 18 May 2020 14:09


Abstract

BACKGROUND: Enhancer of zeste homolog 2 (EZH2) is considered an important driver of tumor development and progression by its histone modifying capabilities. Inhibition of EZH2 activity is thought to be a potent treatment option for eligible cancer patients with an aberrant EZH2 expression profile, thus the indirect EZH2 inhibitor 3-Deazaneplanocin A (DZNep) is currently under evaluation for its ...

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