Paclitaxel, Imatinib and 5-Fluorouracil Increase the Unbound Fraction of Flucloxacillin In Vitro

URN to cite this document:: urn:nbn:de:bvb:355-epub-433514
DOI to cite this document:: 10.5283/epub.43351

Stolte, Maximilian ; Ali, Weaam ; Jänis, Janne

; Gessner, Andre ; El-Najjar, Nahed

Preview

License: Creative Commons Attribution 4.0
PDF - Published Version
(552kB)

Date of publication of this fulltext: 16 Jun 2020 15:17

Alternative links to fulltext:DOI Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

Flucloxacillin (FLU), an isoxazolyl penicillin, is widely used for the treatment of different bacterial infections in intensive care units (ICU). Being highly bound to plasma proteins, FLU is prone to drug-drug interactions (DDI) when administered concurrently with other drugs. As FLU is binding to both Sudlow's site I and site II of human serum albumin (HSA), competitive and allosteric ...