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Paclitaxel, Imatinib and 5-Fluorouracil Increase the Unbound Fraction of Flucloxacillin In Vitro

Stolte, Maximilian ; Ali, Weaam ; Jänis, Janne ; Gessner, Andre ; El-Najjar, Nahed
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Date of publication of this fulltext: 16 Jun 2020 15:17


Abstract

Flucloxacillin (FLU), an isoxazolyl penicillin, is widely used for the treatment of different bacterial infections in intensive care units (ICU). Being highly bound to plasma proteins, FLU is prone to drug-drug interactions (DDI) when administered concurrently with other drugs. As FLU is binding to both Sudlow’s site I and site II of human serum albumin (HSA), competitive and allosteric ...

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