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Considerations for efficient surface functionalization of nanoparticles with a high molecular weight protein as targeting ligand

Thalhauser, Stefanie ; Breunig, Miriam


Functionalization of nanoparticles with ligands is a powerful tool to achieve efficient targeting of receptors expressed on specific cell types. For optimal ligand-receptor interactions, the ligands should be attached on the nanoparticle surface in a predictable manner with specific orientations and density that preserve their bioactivity. While there are many publications on nanoparticles ...


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