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De novo polyamine synthesis supports metabolic and functional responses in activated murine Natural Killer cells

O'Brien, K. L. ; Assmann, Nadine ; O'Connor, E. ; Keane, C. ; Walls, J. ; Choi, C. ; Oefner, Peter J. ; Gardiner, C. M. ; Dettmer, Katja ; Finlay, D. K.


Cellular metabolism is dynamically regulated in NK cells and strongly influences their responses. Metabolic dysfunction is linked to defective NK cell responses in diseases such as obesity and cancer. The transcription factors, sterol regulatory element binding protein (SREBP) and cMyc, are crucial for controlling NK cell metabolic and functional responses, though the mechanisms involved are not ...


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